Abstract
- Ovarian tissue cryopreservation (OTC) is increasingly used for fertility preservation in young women.
- An Australian cohort study examined pregnancy and mortality outcomes of patients who underwent OTC and/or ovarian tissue transplantation (OTT).
- The study found that approximately one in five women achieved a pregnancy, highlighting the feasibility of OTC.
Introduction
- OTC is a fertility preservation option for women unable to undergo oocyte or embryo cryopreservation.
- Australia has been instrumental in advancing OTC, but clinical outcomes are sparsely documented.
- This study addresses the gap in understanding pregnancy outcomes post-OTC, with or without OTT, in Australia.
Materials and methods
- A retrospective cohort study was conducted on women over 18 who underwent OTC and/or OTT at Melbourne IVF between 1995 and 2022.
- Data linkage was used to obtain perinatal and mortality data from Victorian databases.
- Statistical analysis included Kaplan-Meier curves and competing risks regression to assess pregnancy outcomes.
Results
- 593 women who underwent OTC were included, with 48 later undergoing OTT.
- 107 women were reported as deceased, with a significantly lower rate among transplant patients.
- Transplant women had a 25.0% pregnancy rate, compared to 18.7% for nontransplant women, though not statistically significant.
Comment
- The overall pregnancy rate after OTC was 19%, with no statistically significant difference between transplant and nontransplant cases.
- Higher age at OTC and malignant disease were linked to lower pregnancy probabilities.
- The findings demonstrate that pregnancies can be achieved in approximately one in five patients who have undergone OTC, both with and without transplantation.
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I’m glad the post discussed biodiversity. It’s often overlooked in conversations about environmental science, but preserving biodiversity is critical to maintaining healthy ecosystems. We need more initiatives focused on protecting endangered species.
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I think the role of education in environmental science is often underestimated. If we don’t teach the next generation about the importance of sustainability and protecting the planet, then all the advancements we’re making now could be in vain.
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